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Ketamine hydrochloride is a synthetic dissociative anaesthetic. It was first synthesized in the 1960s for medical use, and was first used medicinally during the Vietnam war. Recreationally, it is usually consumed by snorting a white crystalline powder, and at lower doses than when it’s used as an anaesthetic. However it can also be injected, or smoked. It is used in a club setting, but also as a psychedelic.

When ketamine is snorted, it gets in to the blood stream quickly, and intoxication effects occur soon after it’s taken. Although it’s an anaesthetic, at low doses it raises heart rate. It’s also associated with cognitive impairment during intoxication, including to speech and executive function. It can also induce mild psychedelic effects such as perceptual changes and psychotic-like experiences, which are appealing to some users, but can also be distressing. At slightly higher doses, users can experience a dissociative state, where their mind feels separated from their body. This can also manifest as a feeling of depersonalization.Buy Ketamine HCL Online UK, ketamine HCL for sale England, Where to buy Ketamine  Scotland, Order Ketamine solution Northern Ireland,

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At higher doses, the anaesthetic quality of ketamine becomes more pronounced. People may find it difficult to move and may feel numb, and can experience more vivid hallucinations. This is sometimes called the ‘k-hole’ by users. Amnesia can occur at this level of use. This is a particular danger of using ketamine recreationally: users are vulnerable to assault from others in this state, or can put themselves in danger by not being aware of their surroundings (for example being unaware they are outside and it is cold can lead to hypothermia, or being unaware of surroundings could lead to walking in to traffic).

Ketamine can become more dangerous when mixed with other substances. Because of its anaesthetic qualities, it’s dangerous to use ketamine alongside depressants such as alcohol or opiates, as a person increases their risk of passing out or stopping breathing. Conversely, taking ketamine alongside stimulants can put extra pressure on the heart, and also increase the risk of anxiety brought on by heightened arousal, and can lead to symptoms such as palpitations.

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As is the case for a number of illicit recreational drugs, the research in to the long-term effects of using ketamine recreationally is somewhat lacking. However, anecdotal reports that heavy ketamine use is associated with bladder and urinary tract problems are common, and although the mechanism by which ketamine might cause these problems isn’t well known, there is some evidence from case studies of heavy ketamine users that daily use for prolonged periods of time might lead to the thickening of the bladder wall. Heavy users sometimes report cloudy or bloody urine, pain when going to the toilet, and urge incontinence. There has only been one reported case of urinary problems in a person prescribed ketamine for medical reasons.Buy Ketamine HCL Online UK, ketamine HCL for sale England, Where to buy Ketamine  Scotland, Order Ketamine solution Northern Ireland,

There is some evidence that prolonged heavy ketamine use is associated with memory problems. As with many of these studies, it is difficult to know with certainty whether or not there were already pre-existing differences between those who use ketamine, and those who choose not to, but the use of controls who also use other substances hopefully minimizes this problem. Interestingly, a small study of 18 ketamine users and 10 polydrug using controls also found some evidence that semantic memory impairments seen in ketamine users may reverse if a person dramatically cuts down their use. However, the same study found little evidence that impairments to episodic memory and attention improve after cessation.

There is some evidence that ketamine can be addictive to heavy users. It’s also the case that tolerance to the drug can build up, meaning higher doses are required for a user to get the same effect, which can increase the risk of bladder damage.

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Ketamine is on the World Health Organisation’s list of essential medicines, because it’s extremely useful as an anaesthetic in locations where ventilation equipment isn’t available. Although its slight psychedelic effects don’t make it an ideal anaesthetic in general, because it doesn’t impact on breathing rates as much as other anaesthetics do, it’s extremely useful in the field, or in locations where it’s harder to access such equipment. Because it doesn’t lower blood pressure it’s also useful as a painkiller in emergency trauma situations as well.

It’s also used in palliative care and chronic cancer pain in the UK, in particular for individuals who are no longer responding to conventional opioid treatment.

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